Modifiers

Note Animation FPS

 * Changes how fast the notes animate.

Star Animation FPS

 * Changes how fast the star power notes animate.

Gem Size

 * Changes the size of the "gems". (Another name for notes.)

Highway Shake

 * Enables/disables the highway shaking when notes are missed.

Song Preview

 * Enables/disables song previews on the song selection screen.

Menu Music

 * Enables/disables menu music.

Default Sort Filter

 * Changes the initial sorting method.
 * Default is sorting by Song name.

Pause on Focus Lost

 * Enables/disables pausing the game when you click off the game window.

Controller Poll Rate

 * Changes how often the controllers are polled for input.
 * This will increase CPU usage the higher it's set.
 * If this is set higher than the framerate that you have set the game at, there won't be much of a difference.
 * Only accessible and usable if using an Xbox 360 or PS3 guitar.

No Fail

 * Enables/disables the ability to fail.

Mute Track on Miss

 * Enables/disables the audio track muting when a note is missed.

Show Bot Score

 * When there's only bot players, enables/disables the score HUD.

Show Lyrics

 * Enables/disables lyrics in-game.

Instrument
Lets you pick the instrument you want to play as.

Difficulty
Lets you change the difficulty.

Note Modifiers
None All Strums All HOPO's All Taps All Opens Mirror Mode
 * The song plays as it is
 * You have to strum every note
 * Makes every note a hammer on, or a pull off (HOPO)
 * You only need to strum the first note, provided you don't miss any in the song.
 * Makes every note a tap note.
 * You never have to strum.
 * Makes every note an open note.
 * You never have to hit any frets.
 * Swaps the notes so that green plays orange, red plays blue, and yellow stays the same.
 * Basically Lefty Flip but the notes don't change color.